Research Description

We are investigating the complex, dynamic processes of left-right asymmetric organ morphogenesis. Our current focus is on the digestive organs, including the intestine, stomach and liver. We are directly investigating the morphogenetic processes that shape the asymmetrical shape and position of these organs, using the model organism, Xenopus laevis. In addition, we are pursuing Functional Genomics, using Xenopus to assess the in vivo roles of candidate human birth defect genes identified by sequencing the DNA of families with left-right asymmetry defects.